Abstract
Smad4, one of the intracellular messengers of transforming growth factor (TGF)-β signaling pathway, has been paid more and more attention. Lots of studies have proved that Smad4 plays the role of tumor suppressor gene in malignant tumor of female reproductive system. The reduced or deleted expression of Smad4 protein in those tumor tissues can promote the occurence and development of carcinoma. Smad4 is also associated with low survival and poor prognosis of patients with malignant tumor of female reproductive system. With further research, Smad4 may be a valuable marker of diagnosis and evaluation of the prognosis and target of malignancy treatment in malignant tumor of female reproductive system. This review will summarize the research progress of relations between Smad4 and malignant tumor of female reproductive system. Key words: Smad4 protein; Transforming growth factor-β; Neoplasms
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
