Abstract
Smad4, one of the intracellular messengers of transforming growth factor (TGF)-β signaling pathway, has been paid more and more attention. Lots of studies have proved that Smad4 plays the role of tumor suppressor gene in malignant tumor of female reproductive system. The reduced or deleted expression of Smad4 protein in those tumor tissues can promote the occurence and development of carcinoma. Smad4 is also associated with low survival and poor prognosis of patients with malignant tumor of female reproductive system. With further research, Smad4 may be a valuable marker of diagnosis and evaluation of the prognosis and target of malignancy treatment in malignant tumor of female reproductive system. This review will summarize the research progress of relations between Smad4 and malignant tumor of female reproductive system. Key words: Smad4 protein; Transforming growth factor-β; Neoplasms
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