Abstract
Islet β cell dysfunction is one of the important links in the development of type 2 diabetes (T2DM). The latest research shows that the main cause of the continuous β-cell dysfunction under metabolic stress is mainly the dedifferentiation of β-cells, and become endocrine progenitor-like cells with multiple differentiation potentials.Studies have found that the process of dedifferentiation of pancreatic islet β cells is reversible.This finding has provided possibilities and new ideas for preventing and reversing the progressive decline of β cell function and delaying the occurrence of T2DM. Key words: Diabetes mellitus, type 2; Pancreatic beta cells; Cell dedifferentiation; Mechanism; Research progress; Review
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