Abstract
Pituitary adenoma is a serious disease that affects human health through interfering hypothalamus-pituitary-target organ axis systems. Proteomics is an effective approach to elucidate molecular mechanisms of a pituitary adenoma and discover effective biomarkers for a pituitary adenoma. A great progress has been made in the field of pituitary adenoma proteomics in the past ten years: ⑴ the use of laser capture microdissection, ⑵ functional pituitary adenoma proteomics (such as prolactinoma), ⑶ proteomics analysis of invasive characteristics of nonfunctional pituitary adenoma, ⑷ protein post-translational modifications including phosphorylation and tyrosine nitration, ⑸ the use of protein antibody array, ⑹ proteomics analysis of hormone isoforms, ⑺ serum proteomics and peptidomics, ⑻ integration of proteomics and other omics data, and ⑼ proposal of multi-parameter systematic strategy for a pituitary adenoma. Key words: Pituitary neoplasms/ME; Proteome; Review
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