Research on danger of aplastic anemia secondary infection with influenza virus

Abstract

Objective To investigate the influence of influenza virus infection on the hematopoietic function of aplastic anemia model mouse, and provide reference for research on clinical aplastic anemia influenza complication. Methods Small mice aplastic anemia model was set up by cyclophosphamide and toluene method. Through observing changes of hemoglobin and blood three series between model mouse and normal mouse to estimate the molding effect. Virus inoculation method was used to estimate the effects of influenza virus on the blood cell and survival of normal and aplastic anemia mouse. Results Aplastic anemia model mouse with chemical method were successfully established. Hemoglobin, red blood cell, white blood cell and blood platelet were reduced obviously, the differences compared with control group had statistical significance (P<0.05) . In contrast with uninoculated mouse, normal mouse had no significant change in blood three series after less frequent influenza virus inoculation except for temporary body weight loss. However, the fatalily rate of aplastic anemia mouse was increased remarkably after inoculating influenza virus compared to normal mouse). Conclusions Influenza virus has no obvious effect on normal hematopoiesis in mice, but may worsen the condition of aplastic anemia animal and even lead to illness and death. Key words: Anemia, aplastic; Influenza virus; Infection