Abstract
Measurement of the type B Natriuretic peptide(NT-ProBNP) has become a potent diagnostic aid as a means of identifying patients with heart failure.Thefore, we conducted a study assess the effects of NT-proBNP- guided therapy of children with heart failure. Objective: To study the value of the type B Natriuretic peptide (NT-proBNP) in treatment of heart failure in children. Study method: A prospectivecase-control study was carried out. Study patients: 100 children were diagnosed with heart failure and they were also classified into different degrees of heart failure according to modified Ross Heart Failure Classification. The control group had 100 patients without cardiovascular disease. Quantitative serum NT-proBNP concentrations and cardiac ultrasound data were analyzedbefore and after treatment and compared between the treatment group and the control group. Results: NT-proBNP concentration in a disease group (HF) was 1125.26 ± 1823.40 pg/ml. The concentration level in the control group was 26.74 ± 38.79 pg / ml. The difference between the two groups is statistically significant (p <0.01). NT- ProBNP concentrations decrease with the state to improve the level of heart failure after treatmnet. Conclusion: NT-proBNP is valuable to assess the outcomes oftreatmentfor children with heart failure. Keyword: NT-ProBNP, heart failure, children
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