Abstract
BackgroundMyocardial disarray is an important histological feature of hypertrophic cardiomyopathy (HCM) which has been studied post-mortem, but its in-vivo prevalence and extent is unknown. Cardiac Diffusion Tensor Imaging (cDTI) provides information on mean intravoxel myocyte orientation and potentially myocardial disarray. Recent technical advances have improved in-vivo cDTI, and the aim of this study was to assess the interstudy reproducibility of quantitative in-vivo cDTI in patients with HCM.Methods and resultsA stimulated-echo single-shot-EPI sequence with zonal excitation and parallel imaging was implemented. Ten patients with HCM were each scanned on 2 different days. For each scan 3 short axis mid-ventricular slices were acquired with cDTI at end systole. Fractional anisotropy (FA), mean diffusivity (MD), and helix angle (HA) maps were created using a cDTI post-processing platform developed in-house. The mean ± SD global FA was 0.613 ± 0.044, MD was 0.750 ± 0.154 × 10-3 mm2/s and HA was epicardium −34.3 ± 7.6°, mesocardium 3.5 ± 6.9° and endocardium 38.9 ± 8.1°. Comparison of initial and repeat studies showed global interstudy reproducibility for FA (SD = ± 0.045, Coefficient of Variation (CoV) = 7.2%), MD (SD = ± 0.135 × 10-3 mm2/s, CoV = 18.6%) and HA (epicardium SD = ± 4.8°; mesocardium SD = ± 3.4°; endocardium SD = ± 2.9°). Reproducibility of FA was superior to MD (p = 0.003). Global MD was significantly higher in the septum than the reference lateral wall (0.784 ± 0.188 vs 0.750 ± 0.154 x10-3 mm2/s, p < 0.001). Septal HA was significantly lower than the reference lateral wall in all 3 transmural layers (from −8.3° to −10.4°, all p < 0.001).ConclusionsTo the best of our knowledge, this is the first study to assess the interstudy reproducibility of DTI in the human HCM heart in-vivo and the largest cDTI study in HCM to date. Our results show good reproducibility of FA, MD and HA which indicates that current technology yields robust in-vivo measurements that have potential clinical value. The interpretation of regional differences in the septum requires further investigation.
Highlights
Myocardial disarray is an important histological feature of hypertrophic cardiomyopathy (HCM) which has been studied post-mortem, but its in-vivo prevalence and extent is unknown
To the best of our knowledge, this is the first study to assess the interstudy reproducibility of Diffusion Tensor Imaging (DTI) in the human HCM heart in-vivo and the largest Cardiac Diffusion Tensor Imaging (cDTI) study in HCM to date
Our results show good reproducibility of Fractional Anisotropy (FA), Mean Diffusivity (MD) and Helix Angle (HA) which indicates that current technology yields robust in-vivo measurements that have potential clinical value
Summary
Myocardial disarray is an important histological feature of hypertrophic cardiomyopathy (HCM) which has been studied post-mortem, but its in-vivo prevalence and extent is unknown. Disarray may play a key role the in the genesis of the substrate responsible for malignant ventricular arrhythmias and myocardial contractile dysfunction, [4] but to date, insights into the extent and spatial distribution of myocyte disarray have been derived largely from small post-mortem series examining hearts obtained after sudden cardiac death [5,6,7,8] These studies have considerable selection bias and as a result, the in-vivo prevalence and functional consequences of disarray in HCM remain unknown. The diagnostic utility of disarray in HCM is unclear as the phenomenon has been described in a variety of congenital and acquired myocardial diseases [9,10] These include other conditions associated with left ventricular hypertrophy, such as aortic stenosis and hypertensive heart disease, [11] the latter frequently posing a challenge in the differential diagnosis of HCM [12]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have