Abstract
Background In vivo Cardiac Diffusion Tensor Imaging (cDTI) has great potential to depict the microstructure of the myocardium, with Mean Diffusivity (MD), Fractional Anisotropy (FA), and Helix Angle (HA) maps. Quantitative analysis of these parameters might help disease diagnosis, however HA is particularly difficult to quantify as it varies across the myocardial wall. To overcome this, we developed a method to quantify HA deviation from an average healthy map. This technique, together with quantitative FA and MD analysis, have been applied to healthy volunteer data by varying the number of averages to analyse the improvement of the measurements.
Highlights
In vivo Cardiac Diffusion Tensor Imaging has great potential to depict the microstructure of the myocardium, with Mean Diffusivity (MD), Fractional Anisotropy (FA), and Helix Angle (HA) maps
This technique, together with quantitative FA and MD analysis, have been applied to healthy volunteer data by varying the number of averages to analyse the improvement of the measurements
The Cardiac Diffusion Tensor Imaging (cDTI) data of 10 healthy volunteers scanned at 3T during multiple breath-holds at end-systole with a diffusion-weighted STEAM single-shot EPI sequence was used to generate a healthy statistical average LV HA (HSA_HA) map of basal, mid and apical slices (b-value=350s/mm2, 8 averages)
Summary
Cardiac diffusion tensor imaging: helix angle (HA) healthy statistical average technique for HA quantification in vivo. PF Ferreira1*, S Nielles-Vallespin, PD Gatehouse, R de Silva, J Keegan, P Speier, T Feiweier, TG Reese, TF Ismail, A Scott, C Mekkaoui, DE Sosnovik, D Firmin. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013
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