Remarks and further calculations on “Solubility measurement, model evaluation and thermodynamic analysis of rivaroxaban polymorphs in organic solvents”

Abstract

The solubility of form II of anticoagulant drug rivaroxaban in a series of organic solvents was firstly reported by Zhai and coworkers [J. Chem. Thermodynamics 104 (2017) 218–229]. The three activity coefficient models (Wilson, NRTL and UNIQUAC equations) with the correlation between model parameters and temperature were employed to model the studied solid–liquid equilibrium. According to DSC thermograms, rivaroxaban form II has a phase transition between the experimental temperature and the melting point. The authors of published paper must take into consideration that the effect of phase transformation when calculating the activity coefficient of rivaroxaban form II. The Akaike Information Criterion (AIC) was used to compare the relative applicability of these models.