Abstract
Abstract The dissolution thermodynamic properties of polymorphic glycolide in different organic solvents were researched by Huang and coworkers [J. Chem. Thermodynamics 111 (2017) 106–114]. The analysis of Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TG) indicated that glycolide form 1 has a phase transition between the experimental temperature and the melting point. It should be considered that the effect of phase transformation when calculating the activity coefficient of glycolide form 1 by NRTL model. Moreover, the dissolution properties, including Gibbs energy, enthalpy and entropy of form 1 and form 2 were not consistent with the formula ( Δ H dis = Δ G dis + T Δ S dis ) in published paper. In order to get a better understanding of solution behavior, we tried to further calculate and discuss the activity coefficient ( γ 1 ∞ ) and reduced excess enthalpy ( H 1 E, ∞ ) at infinite dilution of glycolide form 1 and form 2 in this work.
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