Abstract
Frog DNA was separated into highly repetitious, moderately repetitious and least repetitious fractions which were hybridized to labeled RNA of isolated nuclei and whole cells of developing frog embryos and adult frog liver. There was a decrease in the number of kinds of D-RNA transcribed by all three classes of DNA in the nuclei during development, but an increase in the number of kinds of D-RNA in whole embryos during development. The thermal stability of heterologous hybrids of mouse and frog DNA indicate that it is the more repetitious sequences which are more conservative. The speculation is advanced that the general transcriptional pattern during development is based on the redundancy of the genome and the time of acquisition of genes during evolution.
Published Version
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