Relationship of the Vitamin D Levels with Various Biochemical Parameters among the Adult Males of Chandigarh, India

Abstract

Background: Vitamin D level in the body is impacted by various biochemical parameters. Age related changes mark a significant role in the regulation of these parameters. Aims and Objectives: The present study intends to assess the correlation of the vitamin D levels with various biochemical parameters among males of various age groups in Chandigarh. Materials and Methods: The sample included 332 males of the age ranging between 30 and 70 years. Vitamin D level of all the participants was estimated by employing chemiluminescence immunoassay method. For the other biochemical parameters, the standard laboratory procedures were deployed. All the subjects were divided into three categories of Vitamin D level, i.e., normal range (>30–100 ng/ml), insufficiency (21–29 ng/ml), and deficiency (0–20 ng/ml) as per the Endocrine Society Guidelines (2011). Results: The mean value of serum phosphorous was found to be higher for males in normal category as compared to the males in the vitamin D deficient and insufficient categories in all age groups. The mean value of parathyroid hormone was minimum among males in vitamin D normal category while the maximum mean value of this parameter was reported in vitamin D deficient males across all the age groups. The serum phosphorous was reported to have a positive association with the vitamin D level in normal (r=0.445**) and deficient (r=0.026) category. Serum calcium presented a positive and significant correlation with the normal vitamin D level (r=0.348**). Parathyroid hormone exhibited a negative and significant correlation with normal vitamin D level (r=-0.792**). Serum creatinine exhibited a negative and significant correlation (r= -0.447**) with the normal vitamin D level in males. The serum alkaline phosphatase displayed a negative and significant association with the vitamin D level in normal category (r=-0.616**) and a positively significant association with vitamin D deficient males (r = 0.285**). Conclusion: Serum phosphorous and serum calcium were found to be positively and significantly associated with the vitamin D level among males whereas parathyroid hormone and serum alkaline phosphatase were reported to be negatively and significantly associated with the vitamin D level overall.