Abstract
Chirality plays a pivotal role in the pharmacological activity of many chemical compounds, as the spatial arrangement of enantiomers can significantly influence their biological effects. Separation of chiral drugs is of great importance in the pharmacological treatment of human diseases because it distinguishes the pharmacological active enantiomer of a chiral drug from the other enantiomer that has low or inactive pharmacological activity or undesirable toxic effects. The availability of novel chiral stationary phases makes the separation of enantiomers effective and rapid. This review presents (i) different chiral stationary phases encountered in chiral chromatography and their various interaction mechanisms with chiral drugs, (ii) types of mobile phases involved in the chiral separation, (iii) various analytic techniques utilized and different methods in chiral separation, (iv) some examples of chiral drugs, (v) factors that affect chiral separation and (vi) significance of chiral separation in the treatment of human diseases.
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