Relationship of the degree of coronary lesion and serum adipokine levels in patients with myocardial infarction

Abstract

Abstract The role of adipokines in the development of myocardial infarction (MI) is being actively discussed. It is of interest to determine the association between the degree of coronary lesion and serum levels of the studied parameters, as well as the prognostic role of these factors in relation to the risk of developing an unfavorable outcome of MI, which is important for choosing the tactics of a therapeutic strategy. Aims Identification of the presence and characteristics of the relationship of the degree of coronary lesions with the levels of adiponectin and leptin in the blood serum of patients with MI. Materials and methods The study included 119 patients with ST-segment elevation MI who signed voluntary informed consent. Depending on the degree of coronary lesion, patients were divided into 3 groups by the SYNTAX Score: 47 moderate (≤22, Group 1), 42 severe (23–31, Group 2) and 30 extremely severe (≥32, Group 3). The concentrations of adiponectin and leptin was determined in blood serum by ELISA on the 1st and 12th days of hospitalization (BioVendor, USA). Statistical analysis was performed using Statistica 9.0. Results The concentrations of the studied parameters in the blood serum of patients on the 1st day of hospitalization were: adiponectin 7.72 (6.5; 13.0) μg/ml, leptin 7.48 (5.98; 12.5) ng/ml. On the 12th day, there was an increase in the level of adiponectin by 1.5 times and a decrease in leptin by 1.6 times. Correlation analysis revealed significant dependences of the degree of coronary lesion according to the SYNTAX Score with the serum adiponectin level both on the 1st (r=−0.48; p=0.01) and on the 12th day (r=−0.44; p=0.02), and leptin level on the 1st (r=0.35; p=0.01) and 12th days (r=0.37; p=0.01). Conclusions The results of this study indicate a relationship between the degree of coronary lesion, assessed by the SYNTAX Score, and the serum adipokine profile in patients with MI. Based on the data obtained, it can be concluded that the studied markers are capable of reflecting the degree of coronary artery disease already on the 1st day of myocardial infarction and the possibility of using the risk of developing myocardial infarction as biomarkers. Funding Acknowledgement Type of funding sources: None.