Relationship between morphometric parameters of epicardial adipose tissue and adipocytokine profile in patients with myocardial infarction

Abstract

Abstract Aims To reveal the relationship between the thickness of epicardial adipose tissue (EAT) and the levels of adiponectin, leptin, interleukins (IL) IL-6, IL-10, IL-12, IL-33 in the blood serum of patients with myocardial infarction. Materials and methods A total of 119 patients with ST-segment elevation myocardial infarction (MI) who signed voluntary informed consent were examined. The thickness of the epicardial adipose tissue of the left and right ventricles (LV EAT and RV EAT, respectively) was assessed using magnetic resonance imaging on an Exelart Atlas 1.5 MR tomograph (Toshiba, Japan). The concentration of the studied parameters was determined in the blood serum of patients by the ELISA method on the 1st and 12th days of hospitalization: adiponectin and leptin (BioVendor, USA), IL-6, IL-10, IL-12, IL-33 (eBiosciens, USA). Statistical analysis was performed using Statistica 9.0. Results The thickness of the LV EAT was 6.3 (4.7; 9.5) mm, the thickness of the EAT RV was 6.8 (4.9; 0.6) mm. The concentrations of the studied parameters in the blood serum of patients on the 1st day of hospitalization: adiponectin 7.72 (6.5; 13.0) μg/ml, leptin 7.48 (5.98; 12.5) ng/ml, IL-6 14.5 (11.6; 21.8) pg/ml, IL-10 1.9 (0.7; 2.5) pg/ml, IL-12 128.7 (66.4; 182.0) pg/ml, IL-33 5.6 (3.4; 7.2) ng/ml. On the 12th day, there was an increase in the level of adiponectin and IL-33 by 1.5 times, IL-10 by 2 times, a decrease in leptin by 1.6 times, IL-6 by 1.4 times and IL-12 by 1.3 times. Correlation analysis revealed a relationship between the thickness of LV EAT and the following parameters in serum: adiponectin level 1st (r=−0.29; p=0.01), IL-10 12st (r=0.36; p=0.03), IL-6 1st (r=−0.64; p=0.046), IL-33 12st (r=0.24; p=0.04). The thickness of the RV EAT correlated with the concentration of IL-12 in the blood serum of patients 12st (r=−0.59; p=0.01). Conclusions The data obtained indicate the presence of a relationship between the morphometric characteristics of EAT and the serum parameters of the adipocytokine profile in patients with MI. Based on this, we can conclude about the ability of the markers under study to reflect the thickness of the EAT and their potential use for the development of methods for correcting pathological activation of adipose tissue in MI. Funding Acknowledgement Type of funding sources: None.