Abstract
Objective To explore the relationship between neonatal blood thyroid-stimulating hormone (TSH) and maternal thyroid function. Methods From May 2000 to August 2009, 615 767 newborns in Weifang City have been screened congenital hypothyroidism (CH) by detecting TSH value of dried blood spots in the Newborn Screening Centre of Weifang City. A total of 195 cases (0.32 ‰, 195/615 767) were diagnosed as CH. Among them, 159 pairs of CH-positive children and their mothers were included in to group A, other 986 pairs of suspected CH children (TSH≥ 15 μIU/mL) and their mothers (not including the CH-positive children) were included into group B. At the same time, 225 pairs of normal children and their mothers who received screening were recruited into control group. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Maternal and Child Health Hospital of Weifang City. Informed consent was obtained from all participants. Mothers in each group excluded patients with abnormal thyroid function and other diseases that may cause thyroid dysfunction. Detected newborn dried blood TSH value to screening for CH. Collected mother's venous blood (2 mL) when the newborn's TSH≥15 μIU/mL, then analyzed the relationship between mother's thyroid function change trend and their newborn's elevated serum TSH by electrochemiluminescence immunoassay system, including maternal serum TSH, total triiodo thyronine(TT3), total thyroxine (TT4), free triiodo thyronine(FT3), free thyroxine (FT4), thyroid peroxidase antibody(TPO-Ab), thyroglobulin (TG), thyroglobulin antibody(TG-Ab). Results ①The thyroid dysfunction of mother in group A was 23.3% (37/159), group B was 7.00% (69/986), and control group was 1.78% (4/225). The difference was significant among three groups by chi-square test (P<0.01). ② There was significant difference of TSH, TPO-Ab, TG and TG-Ab of mother's in group A, B and control group (P<0.01). ③ The incensement of neonatal blood TSH was related to the exception of their mother's TSH, TPO-Ab, TG and TG-Ab (P<0.01). ④Statistical analysis showed that the incidence of CH was positively correlated with the abnormal of mother's TSH (r=0.205), FT3 (r=0.127), FT4 (r=0.206), TPO-Ab (r=0.292), TG (r=0.214), TG-Ab (r=0.236) and was no correlated with mother's TT3 (r=0.015), TT4 (r=0.065). Conclusion ①The incensement of neonatal blood TSH was related to their mother's thyroid dysfunction. ②The newborn elevated TSH was positively correlated with the abnormal of mother's TSH, TPO-Ab, TG and TG-Ab. ③Mother thyroid dysfunction could lead to neonatal CH. Key words: thyroid-stimulating hormone(TSH); congenital hypothyroidism(CH); neonate; mother
Published Version
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