Analysis of the relationship between neonatal TSH level and simple-elevated level of TPOAb in pregnant women

Abstract

Objective By screening the neonatal thyroid stimulating hormone (TSH) and the thyroid peroxidase antibody (TPOAb) in pregnant women, to investigate whether the simple-elevated level of TPOAb in pregnant women during the first trimester of pregnancy affects the thyroid function of the newborn or not. Methods 30 cases of neonates whose mothers had normal thyroid function and normal TPOAb level were selected as control group, 30 cases of neonates whose mothers had normal thyroid function and elevated level of TPOAb (>34 IU/L) were selected as observation group. And then analyzed the difference of neonatal TSH level between the two groups, and the relationship between TPOAb level in pregnant women and neonatal TSH level. Results The neonatal TSH level in the observation group was (2.91±0.10) mIU/L, significantly higher than that in the control group [(1.92±0.18) mIU/L], with statistically significant difference between the two groups (t=-42.29, P<0.001). The correlation analysis showed that the TPOAb level in pregnant women was positively correlated with the neonatal TSH level (r=0.46). Conclusion The elevated level of TPOAb in pregnant women during the first trimester of pregnancy may affect the neonatal thyroid function. Key words: First trimester of pregnancy; Pregnant women; Simple-elevated level of TPOAb; Neonate; TSH