Relationship between the levels of serum HDL, LP (a) and CA72-4 and TNM staging in patients with gastric cancer and its clinical significance

Abstract

Objective To investigate the relationship between the levels of serum lipoprotein a[LP (a)], high density lipoprotein (HDL), carbohydrate antigen 72-4 (CA72-4) and TNM staging in patients with gastric cancer and the clinical significance. Methods From October 2015 to November 2017, 86 cases of gastric cancer in Yuncheng Central Hospital were enrolled in the malignant group and 86 patients with benign gastric disease were selected as benign group. At the same time, 86 cases of healthy physical examination in Yuncheng Central Hospital were selected as control group. On the second day after admission, 4 ml of fasting venous blood were extracted from each group, and the levels of serum LP (a), HDL and CA72-4 were measured. The corresponding treatment measures were taken for patients in malignant group. The levels of serum HDL, LP (a) and CA72-4 before and after treatment of gastric cancer patients in the malignant group, benign group and different TNM stagings were recorded. The relationship between serum HDL, LP (a), CA72-4 and TNM staging was analyzed. Results There were no significant differences in the levels of serum HDL, LP (a) or CA72-4 among the malignant group, the benign group and the control group(P 0.05), and with the increase of TNM stage, the levels of serum LP(a) and CA72-4 increased continuously, and the level of HDL decreased continuously. The serum HDL level after treatment was higher than that before treatment. The levels of LP(a) and CA72-4 were lower than those before treatment (P<0.05). There was negative correlation of the level of serum HDL with the TNM staging of gastric cancer. There was positive correlation of the level of serum LP (a), CA72-4 with TNM staging of gastric cancer(P<0.05). Conclusions The levels of serum HDL, LP(a) and CA72-4 in patients with gastric cancer are abnormal. With the increase of TNM stage, the levels of serum LP(a) and CA72-4 are increasing, and the level of HDL is decreasing. Clinical diagnosis and TNM staging assessment can be performed by detecting the above-mentioned indicators, and it can be used to evaluate the therapeutic effect, and provide reference for further development and adjustment of treatment options. Key words: High density lipoprotein; Serum lipoprotein a; Carbohydrate antigen 72-4; Gastric cancer; TNM staging