Abstract
Background Para and perirenal fat is a fat pad surrounding the kidneys. Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension. We aimed to assess the relationship between para-perirenal ultrasonographic fat thickness and serum high-density lipoprotein (HDL) level and cholesterol efflux capacity of HDL in patients with type 2 diabetes mellitus (T2DM). Methods We recruited 58 subjects with T2DM and collected anthropometric indices including height, weight, waist circumference, and other clinical data. Para-perirenal ultrasonographic fat thickness (PUFT) was measured via ultrasound. Serum lipid profile and other metabolic indices were determined as well. Correlation analysis and regression analysis were performed to analyze the relationship between PUFT and HDL level and cholesterol efflux capacity in all patients and subgroups. Results Patients with higher PUFT have lower serum HDL level but increased cholesterol efflux capacity. Further analysis showed that PUFT negatively correlated with the serum HDL level in all patients, with no difference in groups divided by body mass index (BMI). In addition, PUFT was positively correlated with cholesterol efflux capacity in all patients. Multiple stepwise regression analysis showed an independent association of PUFT and serum HDL level and cholesterol efflux capacity. Conclusions PUFT is closely correlated with the serum HDL level and cholesterol efflux capacity in patients with T2DM.
Highlights
Para and perirenal fat is a fat pad surrounding the kidneys
Glycated hemoglobin A1C (HbA1C) (HA-8180, Japan), serum lipid profile, renal function, liver function, and albuminuria level (AU5811, USA) were measured in the clinical laboratory of our hospital. e area of VAT at the level of the umbilicus was measured via an abdominal dual BIA machine with DUALSCAN HDS-2000 (Omron Healthcare Co., Kyoto, Japan). estimated glomerular filtration rate (eGFR) were calculated using Chinese population-specific formula derived from the Modification of Diet in Renal Disease (MDRD) equation (GFR 175 × (Scr/88.4) − 1.154 × − 0.203 × (0.742 if female)) [21]
All subjects were divided into two groups based on perirenal ultrasonographic fat thickness (PUFT) (
Summary
Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension. We aimed to assess the relationship between para-perirenal ultrasonographic fat thickness and serum high-density lipoprotein (HDL) level and cholesterol efflux capacity of HDL in patients with type 2 diabetes mellitus (T2DM). Correlation analysis and regression analysis were performed to analyze the relationship between PUFT and HDL level and cholesterol efflux capacity in all patients and subgroups. Multiple stepwise regression analysis showed an independent association of PUFT and serum HDL level and cholesterol efflux capacity. PUFT is closely correlated with the serum HDL level and cholesterol efflux capacity in patients with T2DM. Several studies have reported the close relationship between para and perirenal fat and cardiovascular diseases, including atherosclerosis, blood pressure, and endothelial damage [7,8,9,10]
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