Relationship between serum 25-hydroxy vitamin D3 level and function of islet beta cell in newly diagnosed type 2 diabetes

Abstract

Objective To evaluate the serum 25-hydroxy vitamin D 3 level in newly diagnosed type 2 diabe-tes,and its relationship with function of islet beta cell .Methods 60 newly diagnosed type 2 diabetes patients and 48 normal glucose tolerance healthy control cases were selected .The level of serum 25-hydroxy vitamin D3 of two groups were measured using the way of high performance liquid chromatograph .The difference was compared between two groups.Insulin resistance index（HOMA-IR） and islet beta cell secrete index（HOMA-β） was used to respectively es-timate insulin sensitivity and islet beta cell function in type 2 diabetes group .The correlation was analyzed between 25-hydroxy vitamin D 3 and fasting blood glucose ,HOMA-IR,HOMA-β.Results The level of serum 25-hydroxy vita-min D3 （28.68 ±1.61） ng/mL in type 2 diabetes group was significantly lower than that of control group （41.30 ± 1.12）ng/mL（t=3.47,P〈0.01）.There is negative correlation between 25-hydroxyl vitamin D3 and fasting glucose （r=0.48,P〈0.05）.There was positive correlation between 25-hydroxy vitamin D3 and HOMA-IR（r=0.52,P〈0.05）.There was no correlation between 25-hydroxy vitamin D3 and HOMA-β（r=-0.06,P〉0.05）.Conclusion The level of 25-hydroxy vitamin D 3 was significantly low in newly diagnosed type 2 diabetes patients .Low serum 25-hydroxyl vitamin D 3 level affects islet beta secretion cell function ,the supplementation of vitamin D 3 may be a simple and effective method to reduce the ocurrence of type 2 diabetes . Key words: diabetes,type 2 25-hydroxy vitamin D3 ; Insulin resistance index; islet beta cell secrete index