Study on the detection value of 25-hydroxy vitamin D in patients with type 2 diabetic nephropathy

Abstract

Objective To investigate the value of 25-hydroxy vitamin D levels in patients with type 2 diabetic nephropathy. Methods Six hundred type 2 diabetic patients were enrolled in the study. The height, weight and fasting venous blood lipids and 25 hydroxyvitamin D levels were measured, and the urinary albumin excretion rates in one day were calculated, the relationship between diabetic nephropathy and 25 hydroxyvitamin D levels was analyzed. Results There was no significant difference in the gender, age, LDL-C, TC, HbAlc, HDL-C levels, body mass index (BMI), smoking history between the two groups (P<0.05). The TG level, incidences of hypertension, obesity, serum creatinine levels, use of hypoglycemic drugs ratio were higher, the duration of diabetes was longer (P<0.05). The incidence of high blood lipid in macroalbuminuria group was higher than other groups (P<0.05). The vitamin deficiency rates in patients with diabetic nephropathy were significantly higher than those in patients without diabetic nephropathy (P<0.05). The urinary albumin excretion rate in vitamin D deficiency group was significantly higher than that of the other two groups (P<0.05). Women were more likely to have difficiency of vitamin D than men (P<0.05). The decreased HDL-C levels was correlated with lack of vitamin D, and smoking and hyperlipidemia abnormal proportion, HbAlc, duration of diabetes, hypertension were not correlated with vitamin D difficiency. There was a significant negative correlation between UAER and Vitamin D levels (r=-1.792, P<0.01), but the serum creatinine concentration with vitamin D levels was not correlated, and lack of vitamin D could significantly increase the incidence of diabetic nephropathy (P<0.05). Conclusions The patients with type 2 diabetes has low 25-vitamin D levels, and the risk of diabetic nephropathy in patients with type 2 diabetes mellitus increases with the decrease of the level of 25-hydroxy vitamin D. Key words: 25-hydroxy vitamin D; Diabetic nephropathy; Type 2 diabetes mellitus; Urinary albumin excretion rate; Detection value