RELATIONSHIP BETWEEN MALIGNANT TUMOR METABOLISM AND TUMOR-BEARING ORGANISM

Abstract

For a long time, the attention of researchers has primarily focused to the molecular−genetic aspects of the oncogenesis regulation, while quite a logical question remained unclear: where does the cancer cell get an energy for accelerated division? Today the studies have emerged and they prove that specific oncogenes control many other genes, including those responsible for metabolism, which not only maintain high energy levels of their own metabolism, but also alter the supply of glucose and amino acids from healthy microenvironment cells to their advantage. Metabolic disorders are accompanied with a progressive protein−energy deficiency. A feature of this process is the discrepancy between the amount of energy received and that required. There is a sharp rise in energy needs and a pronounced breakdown of body proteins, a decrease in the rate of glucose oxidation with a simultaneous increase in lipid oxidation. Nutrient deficiency leads to a release of its own reserves as a result of the destruction of body tissues. In this regard, the development of ways to block the energy sources and plastic material to enter a cancer cell is being actively discussed in order to improve the effectiveness of treatment of cancer patients. Key words: malignant tumor, metabolism, tumor carrier.