RELATIONSHIP BETWEEN INTEGRAL MARKERS OF METABOLIC STATUS AND VASCULAR STIFFNESS IN PATIENTS WITHOUT CARDIOVASCULAR DISEASE

Abstract

Objective: To evaluate correlation of vascular stiffness (VS) marker – cardio-ankle vascular index (CAVI) with anthropometric, laboratory and integral metabolic markers in patients without cardiovascular diseases (CVD). Design and method: 160 patients (56 men and 104 women) were examined, age median was 39.0 [22.0;57.0] years. All participants underwent anthropometric measurement (waist circumference (WC), hip circumference (HC), neck circumference (NC)), lipid profile (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG)) and blood glucose testing by CardioChek PA. Integral indices LAP (Lipid Accumulation Product), VAI (Visceral Adiposity Index), BFP (Body Fat Percentage), BAI (Body Adiposity Index) were measured. CAVI (VS indicator) was measured by sphygmomanometry on VaSera scanner. Statistical processing of the data was done with STATISTICA 12. Results: Patients were divided into two groups according to the CAVI: normal VS (NVS) and high VS (HVS). In the NVS group age median (30.0 [21.0;53.5]) was lower than in the HVS group (55.0 [48.0;63.0]) (p>0.05). The groups had no statistically significant difference by gender, body mass index, WC, HC, NC, presence of metabolic syndrome (MS), blood pressure, smoking status (p>0.05), TG (p=0.331), HDL (p=0.101). In the HVS group patients with hypertension (p<0.001) and dyslipidemia (p=0.019) were more frequent and blood glucose (p=0.002), TC (p=0.020), LDL (p=0.047) were higher compared to the NVS group. In the HVS group, levels of LAP (55.9 [39.8;105]), VAI (1.20 [0.928;1.33]), BFP (32.7 [27.1;37.9]), were significantly higher than in the NVS group: LAP (22.1 [10.5;39.0]), VAI (1.03 [0.664;1.37]), BFP (25.6 [19.2;28.5]) (p<0.05). The groups had no statistical difference by BAI index (p>0.05). CAVI correlation with TC (r=0.267, p<0.05), LDL (r=0.401, p<0.05), LAP (r=0.469, p<0.05), VAI (r=0.420, p<0.05) and BFP (r=0.501, p<0.05) were obtained. According to multivariate linear regression analysis results independent predictors of elevated VS (high CAVI) were identified: age (B=0.065, st.er=0.006, p<0.001), blood glucose (b=0.339, st.er=0.114, p=0.004), LAP (B=0.024, st.er=0,006, p<0.001), VAI (B=0.673, st.er=0.214, p=0.004). Conclusions: In addition to traditional risk factors definition of integral markers of metabolic status is significant when measuring vascular stiffness in patients at moderate or high CVD risk. CAVI independently correlates with LAP and VAI indices.