Association of measures of central fat accumulation indices with body fat distribution and metabolic, hormonal, and inflammatory parameters in women with polycystic ovary syndrome.

Victor Barbosa Ribeiro,Gislaine Satyko Kogure,Cristiana Libardi Miranda Furtado,Rafael Costa Silva,Iris Palma Lopes,Rui Alberto Ferriani,Rosana Maria Dos Reis,Daiana Cristina Chielli Pedroso

doi:10.20945/2359-3997000000157

Victor Barbosa Ribeiro, Gislaine Satyko Kogure + Show 6 more

Open Access

https://doi.org/10.20945/2359-3997000000157

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Journal: Archives of Endocrinology and Metabolism	Publication Date: Jul 11, 2019
Citations: 14	License type: cc-by

Abstract

To investigate the associations among visceral adiposity index (VAI), lipid accumulation product (LAP), body fat percentage (%), and android/gynoid ratio (A/G ratio) in women with polycystic ovary syndrome (PCOS) and verify if the parameters representative of visceral obesity correlate with and exhibit the same frequency as body composition variables; anthropometric indices; and metabolic, hormonal, and inflammatory parameters. This was a cross-sectional study that included 94 women with PCOS. Hormonal, metabolic, and inflammatory parameters were analyzed in all women. Free androgen index (FAI) and homeostasis model assessment (HOMA-IR), as well as LAP, VAI, and anthropometric indices, were calculated. The regions of interest (ROIs) in body composition and body composition indices were evaluated using a dual X-ray absorptiometry (DXA). Overall, 32 variables were selected as markers of body fat distribution. Among the 32 markers evaluated, 29 correlated with LAP, whereas 25 correlated with VAI, 19 with body fat (%), and 30 with A/G ratio. Additionally, some markers correlated with the four adiposity indices evaluated: ROIs, except for total mass and leg fat (%); body composition (body mass index, waist circumference, and hip circumference) indices; fasting insulin; and C-reactive protein. LAP and VAI may be sensitive measures for screening and preventing metabolic syndrome and insulin resistance in PCOS, with LAP being more sensitive than VAI, and the A/G ratio may be more sensitive than body fat percentage.

Highlights

Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting approximately 5-16% of women in reproductive age and is characterized by at least two of the following conditions: hyperandrogenism, irregular menstrual cycle, and presence of ovarian cysts [1,2]
This study aimed to investigate the associations among visceral adiposity index (VAI), lipid accumulation product (LAP), total body fat percentage, and the A/G ratio and to verify if visceral obesity parameters correlate and with the same frequency as variables of body composition, anthropometric indices, and metabolic, hormonal, and inflammatory parameters
When comparing the normal and obese groups, differences in the mean sex hormonebinding globulin (SHBG) and high-density lipoprotein (HDL) levels were significant, which were lower in the obese group (p < 0.001 and p = 0.007, respectively)

Summary

Introduction

Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting approximately 5-16% of women in reproductive age and is characterized by at least two of the following conditions: hyperandrogenism (clinical or biochemical), irregular menstrual cycle, and presence of ovarian cysts [1,2]. This study aimed to investigate the associations among VAI, LAP, total body fat percentage, and the A/G ratio and to verify if visceral obesity parameters correlate and with the same frequency as variables of body composition, anthropometric indices, and metabolic, hormonal, and inflammatory parameters.

Results

Conclusion