Relationship between hs-CRP and the etiology of children with hand-foot-and-mouth disease

Abstract

Objective To explore the relationship between hs-CRP and the etiology of children with hand-foot-and-mouth disease(HFMD). Methods A total of 1 156 laboratory-confirmed children diagnosed with HFMD by pathogenic detection(detection methods include EV71-CA16 IgM antibody detection and universal real-time fluorescent quantitative RT-PCR detection of enterovirus nucleic acid EV71/CA16/EV) in the Children′s Hospital of Hangzhou were involved in the research from September 2014 to July 2016.The hs-CRP levels in the early days(≤5 days) were recorded, and all data were analyzed with SPSS16.0. Results Of all the 1 156 cases, there were 642 cases with hs-CRP level more than 10mg/dL, of whom 37 cases were infected by EV71(5.8%), 552 cases were infected by EV(86.0%), 53 cases were infected by CA16(8.2%). In 514 cases with hs-CRP level less than 10mg/dL, of whom 298 cases were infected by EV71(58.0%), 152 cases were infected by EV(29.6%), 64 cases were infected by CA16(12.4%). Of cases with hs-CRP>10mg/dL, EV universal type got a significantly higher rate, with statistically significant difference(P<0.05). Of cases with hs-CRP<10mg/dL, EV71 got a significantly higher rate, with statistically significant difference(P<0.05). Conclusion The higher the hs-CRP level of the HFMD, the higher infection rate of EV.The lower the hs-CRP level of the HFMD, the higher infection rate of EV71. Key words: Enterovirus infections; Fluorescent antibody technique; Virulence factors; C-reactive protein; Hand-foot-and-mouth disease; Etiology detection