Abstract
ObjectiveGout flares are the most important clinical feature of the disease. A hypothetical maximum flare occurrence in the preceding six‐months has been suggested to be no flares for a patient acceptable symptom state (PASS) and only one flare for low disease activity (LDA). The aim of this analysis was to determine the relationship between gout flare states (PASS, LDA, and not in LDA or PASS (non‐LDA/PASS)) and patient reported outcomes.MethodsPost hoc analyses of variance were undertaken using data from a 12‐month RCT involving 179 people with gout which compared low‐dose colchicine to placebo for the first six months while starting allopurinol, with a further 6‐month follow‐up. Self‐reported gout flares were collected monthly. HAQ and EQ‐5D‐3L were completed 3‐monthly and the gout‐specific brief illness perception questionnaire was collected at months 0, 6, and 12.ResultsIn the final six months of the study 68 (38%) participants were classified as being in PASS, 34 (19%) as in LDA, and 77 (43%) as non‐LDA/PASS. There was no association between gout flare states and EQ‐5D‐3L or HAQ. There was a statistically significant association between 3/8 eight BIPQ items, with increasing consequences, identity and concern scores across the three states of PASS, LDA, and non‐LDA/PASS.ConclusionThe majority of people were able to achieve gout flare PASS or LDA in the second six months after commencing allopurinol. As flare burden increases, so does the impact of gout on the patient. These findings highlight the importance of flare prevention in the management of gout.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call