Relationship between 24 hours urinous albumin excretion rate and metabolic syndrome related factors

Abstract

Objective To investigate the relationship between 24 hours urinous albumin excretion rate(UAER) and metabolic syndrome related factors.Methods Two hundred and fifty-eight type 2 diabetes mellitus(T2DM) patients were divided into 3 groups according to UAER:normal albuminuria group (NAU) ( ＜ 30 mg/24 h ),microalbuminuria group ( MAU ) ( 30 ～ 299 mg/24 h ) and clinical albuminuria group(CAU) (≥300 mg/24 h).The difference in body mass index(BMI),blood pressure,blood biochemical indicator,24 hours urine uric acid(UUA),insulin secretion index(HOMA-IS),insulin resistance index( HOMA-IR) and insulin sensitive index(ISI) were compared.The Pearson correlation analysis and multivariant stepwise regression analysis were then made.Results When compared with NAU group,the systolic blood pressure( SBP),body mass index( BMI),blood uric acid( UA),UUA,ln( HOMA-IR)and ln( HOMA-IS) increased,ln(ISI) decreased in MAU group (P ＜ 0.05 ).SBP,diastolic blood pressure (DBP),BMI,triglyceride (TG),very low density lipoprotein ( VLDL),UA,UUA and ln ( HOMA-IR) increased,ln(ISI) decreased in CAU group (P ＜ 0.05).When compared with MAU group,TG in CAU group increased (P ＜ 0.05 ).UAER is positively correlated with SBP,TG,VLDL and UA (P ＜0.05).Multivariant stepwise regression analysis revealed that TG,SBP and UA were main influence factors on UAER.Conclusions TG,SBP and UA are main influence factors on UAER of T2DM patients.Control these risk factors may help prevent and control diabetic nephropathy. Key words: Diabetes mellitus; Urinary albumin excretion rate; Metabolic syndrome