Correlation between uric acid level and dyslipidemia in patients with type 1 diabetes mellitus

Abstract

Objective To investigate the clinical characteristics of dyslipidemia as well as relationship between serum uric acid levels and dyslipidemia in patients with type 1 diabetes mellitus(T1DM). Methods From June 2015 to February 2019, a total of 201 patients with T1DM from the Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Soochow University were enrolled as T1DM group, and 136 healthy individuals in health examination center were enrolled as healthy control group. T1DM group was subdivided into T1DM with abnormal blood lipids group and T1DM with normal blood lipids group according to the diagnostic criteria by the Guideline for Prevention and Treatment of Dyslipidemia in Adults in China (2016 Version). Data including age, height, weight, blood pressure, hepatic and renal function, uric acid, fasting glucose, HbA1c, thyroid function, total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were collected. Spearman correlation analysis was used to explore the association between uric acid and other laboratory markers. Binary logistic regression analysis was used to analyze the risk factors of T1DM with dyslipidemia. Results The overall incidence of dyslipidemia in T1DM group was 24.9%(50/201). The highest incidence were observed for low HDL-C level, hypertriglyceridemia, and high LDL-C level, their incidences were 18.9%(38/201), 5.5%(11/201) and 2.0% (4/201) respectively. Compared with healthy control group, the systolic blood pressure, diastolic blood pressure, fasting glucose, HbA1c, triglyceride and LDL-C levels were increased (t=2.105-26.048, all P<0.05), whereas the body mass index, HDL-C, and FT3 were decreased (t=-12.660--4.253, all P<0.05) in T1DM group. Compared with T1DM with normal blood lipids group, the levels of uric acid, HbA1c, fasting C peptide and diastolic blood pressure were increased(t=2.283-3.193, all P<0.05), while the age was decreased(t=-2.300, P=0.023) in T1DM with abnormal blood lipids group. The uric acid level was positively correlated with triglyceride(r=0.199, P<0.05), and negatively associated with HDL-C and age(r=-0.163, -0.319, all P<0.05) in patients with T1DM. The logistic regression analysis showed that uric acid (OR=1.007, 95% CI: 1.002-1.011, P=0.002), diastolic blood pressure (OR=1.064, 95% CI: 1.015-1.116, P=0.010)and HbA1c (OR=1.197, 95% CI: 1.027-1.394, P=0.021) were independent risk factors of dyslipidemia in patients with T1DM. Conclusion Patients with T1DM have dyslipidemia, and the uric acid level may associate with dyslipidemia in patients with T1DM. Key words: Type 1 diabetes mellitus; Dyslipidemia; Uric acid