Analysis of the correlation between serum bilirubin, platelet parameters and cardio-cerebral vascular complications in patients with type 2 diabetes mellitus

Abstract

Objective To investigate the correlation and clinical value between serum bilirubin, platelet parameters and cardio-cerebral vascular complications in type 2 diabetes mellitus (T2DM) patients. Methods A total of 163 T2DM patients in Endocrinology Department of Second People’s Hospital of Anhui Province from January 2017 to April 2019 were enrolled. According to the presence or absence of complications of cardio-cerebral vascular disease (CCVD), they were divided into T2DM group (n=61) and T2DM+ CCVD group (n=102). Another 20 healthy subjects were selected as the control group (NC group). Clinical data and biochemical data of each group were retrospectively analyzed. Results Compared with the T2DM group, age, DM course, fasting glucose, glycosylated hemoglobin, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean platelet volume (MPV) and platelet distribution width (PDW) were higher in T2DM+ CCVD group, while total bilirubin (TBil), indirect bilirubin (IBil), direct bilirubin (DBil), high-density lipoprotein cholesterol (HDL-C) and platelet count (PLT) were lower (all P<0.05). Compared with NC group, MPV and PDW were higher in T2DM group and T2DM+ CCVD group, while TBil, IBil, DBil and PLT were lower with different extent (P<0.05). Pearson correlation analysis showed that TBil was negatively correlated with age, DM course, LDL-C, SBP, MPV and platelet pressure in T2DM+ CCVD group (all P<0.05) and positively correlated with fasting glucose, glycosylated hemoglobin, HDL-C IBil, DBil and PLT (all P<0.05). Regression analysis showed that TBil and HDL-C were independent protective factors for CCVD of T2DM, while the DM course, LDL-C and MPV were independent risk factors. Conclusions CCVD in T2DM patients are associated with serum bilirubin levels and platelet parameters. Serum TBil may be an independent protective factor and MPV may be an independent risk factor for CCVD in T2DM patients. Key words: Diabetes mellitus, type 2; Bilirubin; Mean platelet volume; Diabetic angiopathies