Correlation of platelet parameters and activation markers with carotid artery intima media thickness in patients with type 2 diabetes mellitus

Abstract

Objective To observe the correlation between platelet parameters, platelet activation marker and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus. Methods One hundred and ninety-five type 2 diabetic patients were enrolled in the study.The patients were divided into normal group, CIMT increased group and clot group according to the carotid intima-media thickness. The levels of platelet count(PLT), mean platelet volume(MPV), platelet distribution width(PDW), platelet hematocrit(PCT), urinary 11-dehydro-thromboxane B2 (11-DH-TXB2) and other clinical, biochemical characteristics were measured. The results were statistically analyzed. Results ①The levels of serum LDL-C, MPV, PDW, urinary 11-DH-TXB2 and clinical course in the clot group were higher than those in the CIMT increased group and normal group(P<0.05). ②Compared with normal group, clinical course, serum LDL-C, MPV, PDW and urinary 11-DH-TXB2 were higher in the CIMT increased group(P<0.05). ③With spearman rank correlation test, carotid intima-media thickness was positively associated with age, course, BMI, GLU, GHbA1c, LDL-C, MPV, PDW and urinary 11-DH-TXB2, whereas carotid intima-media thickness was negative associated with HDL-C, PLT(all P<0.05). ④ MPV, PDW and urinary 11-DH-TXB2 were shown as the independent risk factors of CIMT on Logistic regression analysis. Conclusions Platelet activation marker and platelet parameters are associated with carotid intima-media thickness in patients with type 2 diabetes mellitus. Key words: Platelet parameters; Urinary 11-dehydro-thromboxane B2; Type 2 diabetes mellitus; Carotid intima-media thickness