Related factors of frequent recurrence of primary nephrotic syndrome in children

Abstract

Objective To investigate the related factors of frequent recurrence of primary nephrotic syndrome in children. Methods A total of 200 children with primary nephrotic syndrome admitted to Children’s Hospital Affiliated to Zhengzhou University from January 2016 to December 2018 were selected, and their clinical data were collected. The children were divided into frequent recurrence group (93 cases) and non-frequent recurrence group (107 cases) according to the frequency of recurrence. The general situation (gender, age of onset, initial starting season, predisposing factors), initial clinical manifestations, initial laboratory test and urine protein negative conversion time were compared between the two groups. Results There were no significant differences in gender, onset season, predisposing factors and edema sites between frequent recurrence group and non-frequent recurrence group (P>0.05). More children with age 200 mg/(kg·d) were found in frequent recurrence group than those in non-frequent recurrence group (P<0.05). While children with urinary protein negative conversion time less than 4 weeks in frequent recurrence group were less than those in non-frequent recurrence group (P<0.05). Conclusions Age of onset, 24 h urinary protein quantification and urine protein negative conversion time are related to the frequency of recurrence of children with primary nephrotic syndrome. Key words: Primary nephrotic syndrome; Clinical features; Frequency of recurrence