Abstract
The commonly used laboratory markers of coronary involvement in subjects with acute coronary syndrome (ACS) are not yet myocardial ischemia-specific and show a late irreversible involvement of the myocardium. A laboratory test has been searched for in order to distinguish persons with myocardial ischemia and typical CAD symptoms to CAD-free individuals. Reg-Ialpha is the product of Reg-I gene which plays a significant role in myocardial regeneration. 38 individuals with suspicion of acute coronary syndrome were tested on admission, after 2 and 6 hours. In all of them cardiac troponin I, myoglobin, C-reactive protein (CRP) and Reg-I alpha were analysed. Our findings did not support the hypothesis that measurement of Reg-Ia maybe the useful marker of myocardial stress.
Highlights
In the last decade, several communications have reported on the need to search for new, sensitive and early tests of myocardial ischemia allowing early and effective therapy
This need arises from the disadvantages of the commonly used laboratory markers of myocardial ischemia: 1. detection of progressed myocardial necrosis 2. insufficient diagnostic value of the assessment of myocardial ischemia 3. elevated values several hours after the onset of myocardial damage
The regenerating gene (Reg) has been reported to play an important role in various regenerating tissues, but it is unknown whether the Reg gene can be activated in the heart
Summary
Several communications have reported on the need to search for new, sensitive and early tests of myocardial ischemia allowing early and effective therapy. This need arises from the disadvantages of the commonly used laboratory markers of myocardial ischemia (troponins or CK-MB mass): 1. Insufficient diagnostic value of the assessment of myocardial ischemia 3. No clinical studies of Reg-Iα values in individuals with myocardial damages have been carried out but recent paper demonstrated the Reg/Reg receptor system in damaged hearts[1]. Reg-Iα could to have a high diagnostic validity for the assessment of myocardial stress. The aim of the present paper was to assess the possible diagnostic utility for the above-mentioned marker in the diagnosis of acute coronary syndromes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
