Abstract
Guanylins and uroguanylins are natriuretic peptides with different effects in many of tissues. In context with guanylins, the intestine-renal axis is presented. The overproduction of guanylin or uroguanylin leads to secondary diarrhea with stimulation of Cl(-) secretion. A diet high in salt lead especially to increased guanylin and uroguanylin secretion. Interesting applications with guanylins measurement could to be in hypertension diagnosis, monitoring of heart dysfunction treatment, intensive care etc.
Highlights
Guanylin is a peptide recently isolated from the intestine, whose effects are similar to bacterial heat stable enterotoxines.[1, 4]
Uroguanylin and bacterial heat stable enterotoxines form the family of agonists to cyclic guanosine monophosphate
According to recent work it seems that guanylin and uroguanylin are present in a number of tissues, especially in the gastrointestinal tract, in the central nervous system, in reproductive tissue and the lymphatic system
Summary
Guanylin is a peptide recently isolated from the intestine, whose effects are similar to bacterial heat stable enterotoxines.[1, 4]. Uroguanylin and bacterial heat stable enterotoxines form the family of agonists to cyclic guanosine monophosphate (cGMP). Guanylin is produced by mature intestinal caliculus cells together with mucine and D cells found there as well. It is produced as a pro-hormone with low biological activity.[1, 11, 12]. According to recent work it seems that guanylin and uroguanylin are present in a number of tissues, especially in the gastrointestinal tract, in the central nervous system, in reproductive tissue and the lymphatic system
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