Redox signaling in plants

Abstract

Hydrogen peroxide (H2O2) was once considered to be an unavoidable and toxic byproduct of an aerobic lifestyle. However, it is now recognized that endogenous H2O2 plays an important positive role as redox metabolite in cell signaling and it allows cells to rapidly respond to metabolic changes. These H2O2 signaling reactions need to be tightly controlled, and cells have developed elegant adaptive strategies to maintain the cellular redox state in balance to preventing damage. Focusing on structure and function of plant proteins, I will guide you in the world of thiol redox control and oxidative stress survival. – Waszczak, C. et al. Sulfenome mining in Arabidopsis thaliana. Proc Natl Acad Sci U S A 111, 11545-11550 (2014). – Akter, S. et al. DYn-2 Based Identification of Arabidopsis Sulfenomes. Mol Cell Proteomics 14, 1183-1200 (2015). – Bodra, N. et al. Arabidopsis thaliana dehydroascorbate reductase 2: Conformational flexibility during catalysis. Sci Rep 7, 42494 (2017). – Huang, J. et al. Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis. J Exp Bot (2017). – Tossounian, M. A. et al. Disulfide bond formation protects Arabidopsis thaliana glutathione transferase tau 23 from oxidative damage. Biochim Biophys Acta 1862, 775-789 (2018).