Recognizing off target drug effects in the gut and brain

Abstract

It is difficult to recognize off-target drug effects, leading to delays in diagnosis and predisposing patients to additional harms. Key components in the formulation of the correct diagnosis include the temporal sequence of events. The sentinel injury may target the gut and brain because of common intermediary metabolites and neuroactive substrates. The description of the complaint may vary among practitioners. The biggest issue in recognizing off target drug effects is to consider the possibility.