Abstract
Neoadujuvant chemoradiotherapy combined with total mesorectal excision (TME) is the standard treatment modality for locally advanced rectal cancer (LARC).Targeted drugs in LARC neoadjuvant therapy are well tolerated and safety,but compared with conventional neoadjuvant chemoradiotherapy,the pathologic complete response (pCR) rate is not increased.Large sample randomized controlled trials are needed to confirm the effects of targeted drugs in the neoadjuvant treatment of LARC. Key words: Rectal neoplasms; Receptor, epidermal growth factor; Receptors, vascular endothelial growth factor; Neoadjuvant therapy
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