Abstract
Publisher Summary It was first reported that the administration of p -chloroamphetamine and p -chloromethamphetamine to rats causes a prolonged and simultaneous decrease in cerebral 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). The simultaneous decline in the levels of the 5-HT and 5-HIAA and the structural similarity of these amphetamine analogs to p -chlorophenylalanine)—an inhibitor of tryptophan hydroxylase—led to the hypothesis that the chlorinated amphetamines inhibit cerebral tryptophan hydroxylase. The chapter presents certain studies that demonstrate that p -chloroamphetamine can cause an irreversible inactivation of cerebral tryptophan hydroxylase. The inhibition of cerebral tryptophan hydroxylase by p -chloroamphetamine can explain the prolonged reduction in the cerebral levels of 5-HT and 5-HIAA..
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