Abstract
Publisher Summary Nerve fibers containing 5-hydroxytryptamine (5-HT) pass laterally in the brain stem to join the medial forebrain bundle. These nerve fibers are distributed to the frontal cortex, hippocampus, and amygdala. These structures are part of a serotonergic functional unit, which plays a modulatory role in the regulation of adrenocorticotropic hormone (ACTH) secretion. There appears to be a correlation between the daily rhythm of 5-HT content in the limbic system and that of circulating corticosterone, and the treatment with parachlorophenylalanine (PCPA) abolishes the diurnal variation of plasma corticosterone at an intermediate level. In an earlier study, it was reported that drugs that affect the metabolism or action of 5-HT abolish the daily rise in plasma 17-hydroxycorticosteroids in the cat but do not block the response to stress. This chapter presents a comparison between different drug administration regimens and the evaluation of the effects of altering brain 5-HT levels on the daily fluctuation of plasma corticosterone and on the response of the pituitary adrenal system to a noxious stimulus in the rat.
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