Abstract
The anticancer activity of thiamine (vitamin B1) combined with its structural properties and docking studies suggested potential anti-heat shock protein 90α (Hsp90α) activity for this vitamin. In experimental testing, thiamine illustrated anti-Hsp90α IC50 value of 12.5 μM. Therefore, in an attempt to capitalize on the simple structure of thiamine and towards the development of new anti-Hsp90α inhibitors, we prepared and screened 56 pyridinium-based structures tailored to thiamine. The most potent among the prepared compounds illustrated anti-Hsp90α IC50 values of 7.4 and 7.6 μM.
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