Rapid routine determination of some anti-epileptic drugs in serum by gas chromatography

Abstract

Procedures are described for the gas Chromatographic determination of phenytoin (diphenylhydantoin, DPH), carbamazepine and phenobarbital in serum. The sensitivity, accuracy, and specificity are all comparable to those of other methods. The time involved for the procedures is about half an hour and the retention times 1 to 2 min. The capacity for routine analysis in the control of anti-epileptic treatment of patients is therefore considerably higher than that of other methods.