Radiological Progression of Pyogenic Brain Abscess with Antibiotics uses Compared to Surgical Intervention

Abstract

Background: Brain abscess is a worldwide health problem with a high morbidity and mortality rate. It begins as a localized area of cerebritis and develops into an encapsulated will-formed abscess. The Pyogenic brain abscess formation starts when bacteria enter cerebral tissues as with trauma, or contiguous spread from a suppurative focus or through hematogenous dissemination from a distant infection. Methods: The study analyses the effect of antibiotics versus the surgical intervention in the curative treatment of pyogenic brain abscess. It is a retrospective analysis study conducted on a series of 25 patients having various stages of pyogenic brain abscess (BA) diagnosed between January 2018 and January 2023 in our institution. All the patients conducted a standard data collection including clinical assessment, radiological and laboratory investigations, medical treatment (with triple intravenous antibiotics), and surgical abscess aspiration. The surgical and medical treatments were compared depending on the radiological and the clinical improvement. Results: Clinical improvement was temporary for all patients with continuous medical treatment for a short time, without radiological improvement. While after surgical aspiration all patients had dramatic radiological, clinical, and laboratory improvement. Conclusion: The gold standard treatment of brain abscess is surgical intervention. Medical treatment could reduce the clinical effects of brain abscess, but it is not considered as a definitive cure.