Abstract
Chromatin is a nucleohistone complex which exhibits a repeat unit structure. The repeat unit, or nucleosome, is composed of approximately 200 base pairs of DNA wrapped about the surface of an octameric histone core, the latter containing two copies each of the histones H2A, H2B, H3, and H4. Approximately 145 base pairs of DNA that are in intimate contact with the histone core are resistant to nuclease digestion. This region of the nucleosome is called the “core particle”. The remaining DNA which is nuclease accessible is referred to as “linker DNA”.
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