Abstract

Chromatin is a nucleohistone complex which exhibits alternating nuclease accessible and resistant regions.1–12 The repeat unit, or nucleosome, consists of approximately 200 base pairs of DNA and two each of the histones H2A, H2B, H3, and H4. The nuclease resistant region is composed of approximately 140 base pairs of DNA wrapped around the eight-histone aggregate to form a “core particle”.8,9 The remaining 60 base pairs of DNA in the nucleosome unit serve to link core particles, and hence are called “spacer DNA” or “linker DNA”. Neutron scattering studies on isolated core particles have verified the placement of DNA exterior to the protein13 and provided a structural model14–16 for the intact core particle8,9 which is in good agreement with electron microscopy studies of unstained, unfixed samples of H1 depleted core particles.17

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