Abstract
AbstractWithin the framework of semiempirical method of quantum chemical PM3, the possibility of formation of paired stack structures under interaction of fluorouracil with pyrimidine and purine nitrogenous bases of nucleotides has been examined. Possible mechanism of transformation of 2‐deoxyuridine‐5‐monophosphate into metabolite‐5‐fluorin‐2‐deoxyuridine‐5‐monophosphate has been given. The calculations that were made allow to suppose that biotransformation of 5‐FU in 5‐fluorin‐2‐deoxyuridine‐5‐monophosphate, most likely, is carried out not in free nucleotides, but in the structure of DNA in two nucleotide triplets UUC and UGU, including the case when directly two nucleotides of deoxyuridine monophosphate, are transformed into 5‐fluorin‐2‐deoxyuridine‐5‐monophosphate. Cytostatic ability of 5‐FU is increased by its capacity to be selectively embedded into nucleotide triplets creating new chemical compounds that violate matrix RNA formation and accordingly violate protein synthesis. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
