Abstract
A rapid and specific high-performance liquid chromatographic (HPLC) method has been developed for quantitative analysis of famotidine in pharmaceutical dosage forms. The method was applied to medicines on the Turkish market. A LiChrospher RP-18 column, HP-1050 UV-detector and methanol—0·1 M aqueous ammonium acetate (30 : 70) as the solvent system (flow rate 1·0 mL min−1) were used. Quantitative determination of famotidine was carried out at 254 nm wavelength. The method was found to be rapid—under 5 min per assay—and was selective enough to allow the determination of famotidine in the presence of certain excipients.
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