Abstract
BackgroundThe association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA).MethodsA total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year.ResultsThe median inter-scan period was 3.2 (range 2.6–4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0–117.7), group II: 47.2 (6.2–160.4), and group III [highest]: 57.5 (8.4–154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0–20.2), group II: 7.6 (0.5–23.5), and group III: 9.4 (1.4–27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167–2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288–2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors.ConclusionTyG index is an independent predictive marker for the progression of coronary atherosclerosis.Clinical registration ClinicalTrials.gov NCT02803411
Highlights
The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear
Won et al Cardiovasc Diabetol (2020) 19:113 risk of plaque progression (PP) and rapid PP was increased in group III compared to that in group I
Systolic blood pressure (BP), body mass index (BMI), serum triglyceride and fasting blood glucose (FBG) levels, prevalence of male sex, hypertension, diabetes, hyperlipidemia, and the use of aspirin, angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB), and statin were significantly higher in subjects with PP than in those without it
Summary
The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Several cross-sectional studies have reported that TyG index is associated with CAD, especially with coronary artery calcification (CAC) [8, 9]. Longitudinal data on the association between TyG index and coronary plaque progression (PP) is scarce. Coronary computed tomography angiography (CCTA) is a well-established non-invasive imaging tool with high diagnostic performance for coronary atherosclerosis and predictive value for adverse CV events [10,11,12,13]. We aimed to examine the association between baseline TyG index and coronary PP using serial CCTA
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