Abstract
A fast and sensitive high performance chromatographic method for quantification of sodium alendronate was developed and afterward implemented for tablet content and dissolution test. Sodium alendronate reference standard and samples of two different commercial tablets were used. The analysis was performed using an anion exchange column at 30°C and a mixture of nitric acid 1.5 mM and copper II nitrate 0.5 mM (50:50, v/v) as the mobile phase. The analysis run time was 15 minutes and the detection was measured at 240 nm. The limit of detection was approximately 0.3 µg mL−1 and the limit of quantification was 0.9 µg mL−1. The within day and between day precision were 0.64 and 1.52%, respectively. The accuracy results showed a recovery range from 99.87 to 101.07%. The validated method was applied to the tablets content and tablet dissolution assays successfully.
Published Version
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