Abstract
This article describes the synthesis of pyrimido[4,5-b]quinoline-2-thiol/ol (3a/3b) by microwave irradiation technique. The dynamic interaction of compounds with deoxyribonucleic acid (DNA) was investigated by absorption spectra, viscosity measurements, and thermal denaturation studies. Intrinsic binding constants (K b ) had values 3.1×106 for 3a and 2.3×105 for 3b. The proposed DNA binding mode supports the large enhancement in the relative viscosity of calf thymus (CT-DNA) on binding to compounds. Results suggest that 3a/3b can bind to CT-DNA by intercalation via the aromatic ring into the base pairs of DNA. Moreover, efficient DNA damage was observed on oxidative cleavage in the presence of 3a/3b.
Published Version
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