PVA Nanofibers Containing Ofloxacin-Cyclodextrin Inclusion Complex: Improve Optical Stability of Ofloxacin

Mohammad Mehrizi,Seyed Hajir Bahrami,Sahar Amiri

doi:10.4236/ojopm.2019.92002

Abstract

Ofloxacin is an antibiotic with a wide range of activity against bacterial infections, but due to the high potential for toxicity when exposed to light, resolving this problem and further stabilizing the drug are among the posed challenges. Inclusion complex formation between α-cyclodextrin (α-CD), ofloxacin (OFL) and polyethylene glycol (PEG) was prepared via two methods to produce nanocontainers with desirable stability. The effect of PEG as compatible solubilizing agent and mixing condition (in ultrasonic bath) were investigated in formation of an inclusion complex between α-CD/OFL. Obtained complexes were examined by FTIR, H-NMR, SEM, EDX and UV which indicated the formation of an inclusion complex between α-CD/OFL, in turn, is a mixture of the cage and channel structures. Differences between 1H-NMR, FTIR and XRD spectra of OFL, CDs and inclusion complex indicated the formation of α-CD/OFL and supramolecular containers in solid phase. These inclusion complexes loaded in PVA-based nanofibers for smart nanofibers with controlled release manner and higher stability of OFL. Obtained nanofiber showed that nanofibers containing CDs/OFL under sonic energy containing higher degree of OFL.

Highlights

Today, the effects of light and resulting toxicity on many medicines have been established [1] [2]
Ofloxacin is an antibiotic with a wide range of activity against bacterial infections, but due to the high potential for toxicity when exposed to light, resolving this problem and further stabilizing the drug are among the posed challenges
Obtained complexes were examined by FTIR, H-NMR, Scanning electron microscopy (SEM), EDX and UV which indicated the formation of an inclusion complex between α-CD/OFL, in turn, is a mixture of the cage and channel structures

Summary

Introduction

The effects of light and resulting toxicity on many medicines have been established [1] [2]. Due to the exposure to direct light, in addition to reducing the amount of drug activity, the substances resulting from photodegradation are highly reactive and toxic and their consumption will lead to serious problems for the patient. Tiefenbacher et al (1994), investigated that the photodegradation of fluoroquinolones, such as ciprofloxacin, ofloxacin and fleroxacin by ultraviolet irradiation and natural room light in liquid medium [3]. In the most optimistic case, it can be said that the efficacy of the drug is reduced to some extent, but this is often not the case, and the side effects that appear due to the formation of degradation-induced substances are very dangerous and important (Scheme 1) [3]

Methods

Results

Conclusion