PCL-based nanofibers loaded with ciprofloxacin/cyclodextrin containers

Abstract

Ciprofloxacin is a broad-spectrum antibiotic with poor solubility and low dissolution rate in the aqueous gastro-intestinal fluids, which limited its bioavailability. Supramolecular containers of ciprofloxacin/CDs were prepared by inclusion complex (IC) forming between ciprofloxacin and CDs (α-CD and β-CD) at various conditions (at room temperature and under sonic energy) were synthesized. The structure of supramolecular containers was characterized by 1H-NMR, X-ray diffraction (XRD), scanning electron microscopy and (FTIR) Fourier-transform infrared spectroscopy. Differences between 1H-NMR, FTIR and XRD spectra of ciprofloxacin, CDs and inclusion complex indicated the formation of ciprofloxacin/α-CD and ciprofloxacin/β-CD supramolecular containers in solid phase. DSC thermographs showed that melting peak of ciprofloxacin did not disappear completely which indicated partial encapsulation of ciprofloxacin in CDs cavity. These inclusion complexes loaded in poly (ε-caprolactone)-based nanofibers for smart nanofibers with controlled release manner. Obtained nanofibers showed that CDs/ciprofloxacin under sonic energy contain higher degree of ciprofloxacin.