PVA nanofibers containing ofloxacin/α-cyclodextrin inclusion complexes: improve ofloxacin water solubility

Abstract

Ofloxacin (OFL) is an antibiotic with a wide range of bacterial infections but its low water solubility and photo stability restricts its applications, so improve its solubility and stability is a challenge. Inclusion complex formation between α-cyclodextrin (α-CD) and OFL was prepared under various circumstances to obtained desirable water solubility. The effect of polyethylene glycol physiologically compatible solubilizing agent and mixing condition were investigated in the formation of an inclusion complex between α-CD/OFL. FTIR, H-NMR, DSC and XRD results indicated the formation of an inclusion complex between α-CD/OFL. Phase solubility test for obtaining α-CD/OFL complexes indicated a rise in aqueous solubility of OFL and formation of inclusion complexes and obviating OFL aqueous solubility limitation. SEM and EDX results indicated OFL/CD/PVA nanofibers without beading defect. Antibacterial activities of OFL/CD nanoparticles were investigated by them inhabitation of bacteria growth. Obtained nanofibers showed significant antibacterial effect against Escherichia Coli and Staphylococcus aureus.