Abstract
Ofloxacin (OFL) is an antibiotic with a wide range of bacterial infections but its low water solubility and photo stability restricts its applications, so improve its solubility and stability is a challenge. Inclusion complex formation between α-cyclodextrin (α-CD) and OFL was prepared under various circumstances to obtained desirable water solubility. The effect of polyethylene glycol physiologically compatible solubilizing agent and mixing condition were investigated in the formation of an inclusion complex between α-CD/OFL. FTIR, H-NMR, DSC and XRD results indicated the formation of an inclusion complex between α-CD/OFL. Phase solubility test for obtaining α-CD/OFL complexes indicated a rise in aqueous solubility of OFL and formation of inclusion complexes and obviating OFL aqueous solubility limitation. SEM and EDX results indicated OFL/CD/PVA nanofibers without beading defect. Antibacterial activities of OFL/CD nanoparticles were investigated by them inhabitation of bacteria growth. Obtained nanofibers showed significant antibacterial effect against Escherichia Coli and Staphylococcus aureus.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
